When lively Emily Elizabeth was given a little red puppy as a present, she never thought it possible that one day she would wake up in her New York flat next to a huge, three-metre-tall dog. While her single mother is away on business, Emily and her funny but rather impulsive Uncle Casey embark on a fantastic journey together, experiencing the most exciting and coolest adventures. Together the three of them conquer New York and Clifford shows the world what it means to have a big heart.